Proteobacteria-specific IgA regulates maturation of the intestinal microbiota.

Abstract

The intestinal microbiota changes dynamically from birth to adulthood. In this study we identified γ-Proteobacteria as a dominant phylum present in newborn mice that is suppressed in normal adult microbiota. The transition from a neonatal to a mature microbiota was in part regulated by induction of a γ-Proteobacteria-specific IgA response. Neocolonization… (More)
DOI: 10.4161/gmic.26489

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