Proteinuria and leg ulcers in homozygous sickle cell disease.

  title={Proteinuria and leg ulcers in homozygous sickle cell disease.},
  author={Anthony G Morgan},
  journal={The Journal of tropical medicine and hygiene},
  volume={85 5},
In a survey of 407 patients with homozygous sickle cell disease in Jamaica, 50 had proteinuria of '+' or more on dipstick testing and 231 had had leg ulcers. Both proteinuria and ulcers began to occur mainly in the second decade of life and their prevalence increased with age thereafter. When allowance was made for this there was no significant association between the two, and it is therefore likely that they result from independent effects of the haemoglobinopathy on the kidneys and skin… CONTINUE READING

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