Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells.

@article{Kikonyogo2001ProteinsRT,
  title={Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells.},
  author={A Kikonyogo and Fadila Bouamr and Marcy L Vana and Youbin Xiang and Ashok Aiyar and Carol A Carter and Jonathan Leis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 20},
  pages={11199-204}
}
The late assembly (L) domain of retrovirus Gag, required in the final steps of budding for efficient exit from the host cell, is thought to mediate its function through interaction with unknown cellular factors. Here, we report the identification of the Nedd4-like family of E3 ubiquitin protein ligases as proteins that specifically interact with the Rous sarcoma virus (RSV) L domain in vitro and in vivo. We screened a chicken embryo cDNA expression library by using a peptide derived from the… CONTINUE READING

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