Proteins identified as targets of the acyl glucuronide metabolite of mycophenolic acid in kidney tissue from mycophenolate mofetil treated rats.

@article{Asif2007ProteinsIA,
  title={Proteins identified as targets of the acyl glucuronide metabolite of mycophenolic acid in kidney tissue from mycophenolate mofetil treated rats.},
  author={Abdul R Asif and Victor William Armstrong and Antje Voland and Eberhard Wieland and Michael Oellerich and Maria Shipkova},
  journal={Biochimie},
  year={2007},
  volume={89 3},
  pages={
          393-402
        }
}
Covalent binding of the acyl glucuronide (AcMPAG) metabolite of the immunosuppressant mycophenolic acid (MPA) to proteins is considered a possible initiating event for organ toxicity. Since the kidney is involved in the formation and excretion of AcMPAG, it can be hypothesized that this tissue may be exposed to relatively high concentrations of this metabolite and would, therefore, be a particularly suitable organ to investigate AcMPAG protein targets. In the present study we identified… CONTINUE READING
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