Proteins derived from latex of C. procera maintain coagulation homeostasis in septic mice and exhibit thrombin- and plasmin-like activities

@article{Ramos2012ProteinsDF,
  title={Proteins derived from latex of C. procera maintain coagulation homeostasis in septic mice and exhibit thrombin- and plasmin-like activities},
  author={M{\'a}rcio V Ramos and Carolina Ara{\'u}jo Viana and Ayrles Fernanda Brand{\~a}o Silva and Cl{\'e}verson Diniz Teixeira De Freitas and Ingrid Samantha Tavares de Figueiredo and Raquel Santos de Oliveira and Nylane Maria Nunes de Alencar and Jos{\'e} Vitor Moreira Lima-Filho and V. N. Lakshman Kumar},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2012},
  volume={385},
  pages={455-463}
}
The proteins derived from the latex (LP) of Calotropis procera are well known for their anti-inflammatory property. In view of their protective effect reported in the sepsis model, they were evaluated for their efficacy in maintaining coagulation homeostasis in sepsis. Intraperitoneal injection of LP markedly reduced the procoagulation and thrombocytopenia observed in mice infected with Salmonella; while in normal mice, LP produced a procoagulant effect. In order to understand its mechanism of… CONTINUE READING

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