Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response.

@article{McDuffee1997ProteinsCN,
  title={Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response.},
  author={A T McDuffee and Guillermo A. Senisterra and S. Huntley and James R. Lepock and Konjeti Raja Sekhar and Michael J. Meredith and Michael J. Borrelli and Jason D. Morrow and Michael L Freeman},
  journal={Journal of cellular physiology},
  year={1997},
  volume={171 2},
  pages={143-51}
}
While oxidative stress can induce a heat shock response, the primary signals that initiate activation have not been identified. To identify such signals, HepG2 and V 79 cells were exposed to menadione, a compound that redox-cycles to generate superoxide. The oxidative stress generated by menadione resulted in oxidation of protein thiols in a dose-dependent manner. This was followed by protein destabilization and denaturation, as determined by differential scanning calorimetry of whole cells. To… CONTINUE READING

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