Proteins binding to duplexed RNA: one motif, multiple functions.

  title={Proteins binding to duplexed RNA: one motif, multiple functions.},
  author={Ivo Fierro-Monti and Michael B. Mathews},
  journal={Trends in biochemical sciences},
  volume={25 5},
Highly structured and double-stranded (ds) RNAs are adaptable and potent biochemical entities. They interact with dsRNA-binding proteins (RBPs), the great majority of which contain a sequence called the dsRNA-binding motif (dsRBM). This approximately 70-amino-acid sequence motif forms a tertiary structure that interacts with dsRNA, with partially duplexed RNA and, in some cases, with RNA-DNA hybrids, generally without obvious RNA sequence specificity. At least nine families of functionally… CONTINUE READING

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