Proteins binding to 5' untranslated region sites: a general mechanism for translational regulation of mRNAs in human and yeast cells.

@article{Stripecke1994ProteinsBT,
  title={Proteins binding to 5' untranslated region sites: a general mechanism for translational regulation of mRNAs in human and yeast cells.},
  author={Renata Stripecke and Carla Columbano Oliveira and John G. McCarthy and Matthias W. Hentze},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 9},
  pages={5898-909}
}
We demonstrate that a bacteriophage protein and a spliceosomal protein can be converted into eukaryotic translational repressor proteins. mRNAs with binding sites for the bacteriophage MS2 coat protein or the spliceosomal human U1A protein were expressed in human HeLa cells and yeast. The presence of the appropriate binding protein resulted in specific, dose-dependent translational repression when the binding sites were located in the 5' untranslated region (UTR) of the reporter mRNAs. Neither… CONTINUE READING

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