Proteins associated with RNase E in a multicomponent ribonucleolytic complex.

  title={Proteins associated with RNase E in a multicomponent ribonucleolytic complex.},
  author={A Miczak and Vladimir R. Kaberdin and Chia Lin Wei and Sue Lin-Chao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 9},
The Escherichia coli endoribonuclease RNase E is essential for RNA processing and degradation. Earlier work provided evidence that RNase E exists intracellularly as part of a multicomponent complex and that one of the components of this complex is a 3'-to-5' exoribonuclease, polynucleotide phosphorylase (EC To isolate and identify other components of the RNase E complex, FLAG-epitope-tagged RNase E (FLAG-Rne) fusion protein was purified on a monoclonal antibody-conjugated agarose… CONTINUE READING
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