Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli

@inproceedings{Yosef2012ProteinsAD,
  title={Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli},
  author={Ido Yosef and Moran G. Goren and Udi Qimron},
  booktitle={Nucleic acids research},
  year={2012}
}
The clustered regularly interspaced short palindromic repeats and their associated proteins (CRISPR/Cas) constitute a recently identified prokaryotic defense mechanism against invading nucleic acids. Activity of the CRISPR/Cas system comprises of three steps: (i) insertion of alien DNA sequences into the CRISPR array to prevent future attacks, in a process called 'adaptation', (ii) expression of the relevant proteins, as well as expression and processing of the array, followed by (iii) RNA… CONTINUE READING
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