Proteinoid microspheres more stable in hot than in cold water.

@article{Syren1985ProteinoidMM,
  title={Proteinoid microspheres more stable in hot than in cold water.},
  author={R. M. Syren and A. Sanjur and S. Fox},
  journal={Bio Systems},
  year={1985},
  volume={17 4},
  pages={
          275-80
        }
}
The occurrence of organisms of primitive appearance near submarine hydrothermal vents has indicated sea-floor conditions that are like those under which proteinoid microspheres are produced in the laboratory. Experimental examination of the question of whether some proteinoid microspheres might be stable in hot water has revealed proteinoids that are soluble in cold water but precipitate on heating. Unanswered questions are discussed. 
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References

SHOWING 1-10 OF 27 REFERENCES
A model for the origin of stable protocells in a primitive alkaline ocean.
When a mixture of the eighteen proteinous amino acids are suitably heated in the dry state with seawater salts, a copolyamino acid results. One fraction of this polymer is found, through isoelectricExpand
Organic Microspheres from the Precambrian of South-West Africa
Quartz crystals from the Precambrian of South-West Africa contain organic particles in their inclusions which closely resemble, in detailed morphology, coacervates, proteinoid microspheres, or fossilExpand
Studies on an Extreme Thermophile
The growth of microorganisms under such extreme environmental conditions as high salt content, low or high temperatures, and very low pH has been known for many years. Thermophiles, microorganismsExpand
Ancient microspheres: abiogenic, protobiogenic, or biogenic?
Criteria of biogenicity of microspheroidal objects, which have been interpreted as microfossils, are here reviewed in the light of additional data. Much weight has been placed by some commentators onExpand
An Hypothesis Concerning the Relationships Between Submarine Hot Springs and the Origin of Life on Earth
A diverse set of observations from Archaean fossil-bearing rocks, modern submarine hydrothermal systems, experimental and theoretical work on the abiotic synthesis of organic molecules and primitiveExpand
Thermal polyamino acids: synthesis at less than 100 degrees C.
TLDR
Three different sets of amino acid mixtures were found to yield material of relatively high molecular weight when heated for up to 81 days at 85 degrees, 75 degrees, and 65 degrees C, suggesting that prebiotic polyamino acids may have been relatively common and widespread. Expand
The Evolution of Individuality at the Molecular and Protocellular Levels
The most important bioelements (= organoelements) hydrogen, carbon, oxygen and nitrogen, are also the most abundant elements throughout the Universe besides helium, neon, and silicon (Fig, 1). In theExpand
The assembly and properties of protobiological structures: the beginnings of cellular peptide synthesis.
TLDR
New data indicate that lysine-rich proteinoids have the ability to catalyze the synthesis of peptide bonds from a variety of amino acids and ATP, inferring that the first protocells on Earth already had a number of biological types of activity. Expand
Stereomolecular interactions and microsystems in experimental protobiogenesis.
  • S. Fox
  • Biology, Medicine
  • Bio Systems
  • 1975
A theory on the origin of the first reproducing (in the sense of Fox, 1973) cells on earth is presented. A degree of self-ordering has been observed in the selective thermal reactions of certain onesExpand
On the experimental silicification of microorganisms II. On the time of appearance of eukaryotic organisms in the fossil record
TLDR
Many, if not all, of the criteria for assessing fossil eukaryotic microorganisms are subject to serious criticism in interpretation, as studied a large variety of prokaryotic algae, some eukarian algae, fungi, protozoa, and abiotic organic microspheres stable at essentially neutral pH. Expand
...
1
2
3
...