Proteinases of the cornea and preocular tear film.

  title={Proteinases of the cornea and preocular tear film.},
  author={Franck J Ollivier and Brian Gilger and Kathleen P Barrie and Maria E. Kallberg and Caryn E. Plummer and S. B. O'Reilly and Kirk N. Gelatt and Dennis E. Brooks},
  journal={Veterinary ophthalmology},
  volume={10 4},
Maintenance and repair of corneal stromal extracellular matrix (ECM) requires a tightly coordinated balance of ECM synthesis, degradation and remodeling in which proteolytic enzymes (proteinases) perform important functions. There are natural proteinase inhibitors present in preocular tear film (PTF) and cornea simultaneously with proteinases that prevent excessive degradation of normal healthy tissue. Disorders occur when there is an imbalance between proteinases and proteinase inhibitors in… CONTINUE READING


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