Proteinases as hormones: targets and mechanisms for proteolytic signaling.

@article{Hansen2008ProteinasesAH,
  title={Proteinases as hormones: targets and mechanisms for proteolytic signaling.},
  author={Kristina K. Hansen and Katerina Oikonomopoulou and Amos Baruch and Rithwik Ramachandran and Paul David Beck and Eleftherios P Diamandis and Morley D Hollenberg},
  journal={Biological chemistry},
  year={2008},
  volume={389 8},
  pages={971-82}
}
Proteinases, such as kallikrein-related peptidases, trypsin and thrombin, can play hormone-like 'messenger roles in vivo. They can regulate cell signaling by cleaving and activating a novel family of G-protein-coupled proteinase-activated receptors (PARs 1-4) by unmasking a tethered receptor-triggering ligand. Short synthetic PAR-derived peptide sequences (PAR-APs) can selectively activate PARs 1, 2 and 4, causing physiological responses in vitro and in vivo. Using the PAR-APs to activate the… CONTINUE READING

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