Proteinases and restenosis in the human coronary artery: extracellular matrix production exceeds the expression of proteolytic activity.

@article{Tyagi1995ProteinasesAR,
  title={Proteinases and restenosis in the human coronary artery: extracellular matrix production exceeds the expression of proteolytic activity.},
  author={Suresh C Tyagi and Laure Meyer and Richard A Schmaltz and Hanumanth K. Reddy and Donald J. Voelker},
  journal={Atherosclerosis},
  year={1995},
  volume={116 1},
  pages={43-57}
}
To understand the balance of proteinase antiproteinase activity and the production of extracellular matrix (ECM) at the site of arterial injury, we analyzed the composition of ECM and proteinase activity in normal internal mammary arteries, tissue samples obtained from atherosclerotic coronary lesions and restenotic lesions obtained during directional coronary atherectomy. Histologically and biochemically, collagen and proteoglycans increased, and elastin decreased in samples from restenotic… CONTINUE READING
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