Proteinase inhibitor 6 cannot be secreted, which suggests it is a new type of cellular serpin.

@article{Scott1996ProteinaseI6,
  title={Proteinase inhibitor 6 cannot be secreted, which suggests it is a new type of cellular serpin.},
  author={Fiona L. Scott and Paul B. Coughlin and Colin Bird and Loretta Cerruti and John A. Hayman and Phillip I Bird},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 3},
  pages={1605-12}
}
We have recently described a new serine proteinase inhibitor, proteinase inhibitor 6 (PI-6). This serpin has features that suggest it may function intracellularly, but its close resemblance to ovalbumin serpins like plasminogen activator inhibitor 2 (PAI-2) raises the possibility that it is secreted to regulate an extracellular proteinase. To determine whether PI-6 is secreted, we have examined its cellular distribution by immunohistochemistry and have attempted to induce its release from… CONTINUE READING
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