Proteinase-activated receptors.

  title={Proteinase-activated receptors.},
  author={Scott R Macfarlane and Michael J Seatter and Toru Kanke and Gary L. Hunter and Robin J Plevin},
  journal={Pharmacological reviews},
  volume={53 2},
Proteinase-activated receptors are a recently described, novel family of seven-transmembrane G-protein-coupled receptors. Rather then being stimulated through ligand receptor occupancy, activation is initiated by cleavage of the N terminus of the receptor by a serine protease resulting in the generation of a new tethered ligand that interacts with the receptor within extracellular loop-2. To date, four proteinase-activated receptors (PARs) have been identified, with distinct N-terminal cleavage… CONTINUE READING
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