Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response.

@article{Steinhoff2005ProteinaseactivatedRT,
  title={Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response.},
  author={Martin S Steinhoff and Joerg Buddenkotte and Victoria M. Shpacovitch and Anke Rattenholl and Corinna Moormann and Nathalie Vergnolle and Thomas Anton Luger and Morley D Hollenberg},
  journal={Endocrine reviews},
  year={2005},
  volume={26 1},
  pages={1-43}
}
Serine proteinases such as thrombin, mast cell tryptase, trypsin, or cathepsin G, for example, are highly active mediators with diverse biological activities. So far, proteinases have been considered to act primarily as degradative enzymes in the extracellular space. However, their biological actions in tissues and cells suggest important roles as a part of the body's hormonal communication system during inflammation and immune response. These effects can be attributed to the activation of a… CONTINUE READING
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