Proteinase-activated receptors: novel signals for peripheral nerves

  title={Proteinase-activated receptors: novel signals for peripheral nerves},
  author={Nathalie Vergnolle and Mara Ferazzini and Michael R. D'Andrea and Joerg Buddenkotte and Martin Steinhoff},
  journal={Trends in Neurosciences},
The discovery of proteinase-activated receptors (PARs) in the nervous system has led to new insights about the potential physiological functions of these enzymes, which were traditionally considered merely as degradative molecules. This review summarizes evidence that proteinases, through activation of PARs, interact with the peripheral nervous system (PNS), playing roles in neurogenic inflammation, pain perception, secretory and motor functions, as well as in the response to nerve injuries… CONTINUE READING


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