Proteinase-activated receptor-2 transactivation of epidermal growth factor receptor and transforming growth factor-β receptor signaling pathways contributes to renal fibrosis.

@article{Chung2013ProteinaseactivatedRT,
  title={Proteinase-activated receptor-2 transactivation of epidermal growth factor receptor and transforming growth factor-β receptor signaling pathways contributes to renal fibrosis.},
  author={Hyunjae Chung and Rithwik Ramachandran and Morley D Hollenberg and Daniel A Muruve},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 52},
  pages={37319-31}
}
Chronic kidney diseases cause significant morbidity and mortality in the population. During renal injury, kidney-localized proteinases can signal by cleaving and activating proteinase-activated receptor-2 (PAR2), a G-protein-coupled receptor involved in inflammation and fibrosis that is highly expressed in renal tubular cells. Following unilateral ureteric obstruction, PAR2-deficient mice displayed reduced renal tubular injury, fibrosis, collagen synthesis, connective tissue growth factor (CTGF… CONTINUE READING
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