Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease.

@article{AfkhamiGoli2007ProteinaseactivatedRE,
  title={Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease.},
  author={Amir Afkhami-Goli and Farshid Noorbakhsh and Avril J Keller and Nathalie Vergnolle and David Westaway and Jack H. Jhamandas and Patricia Andrade-Gordon and Morley D Hollenberg and Hosseinali Arab and Richard H Dyck and Christopher Power},
  journal={Journal of immunology},
  year={2007},
  volume={179 8},
  pages={5493-503}
}
The proteinase-activated receptors (PARs) are a novel family of G protein-coupled receptors, and their effects in neurodegenerative diseases remain uncertain. Alzheimer's disease (AD) is a neurodegenerative disorder defined by misfolded protein accumulation with concurrent neuroinflammation and neuronal death. We report suppression of proteinase-activated receptor-2 (PAR2) expression in neurons of brains from AD patients, whereas PAR2 expression was increased in proximate glial cells, together… CONTINUE READING
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