Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases.

@article{Dulon2003ProteinaseactivatedRA,
  title={Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases.},
  author={Sophie Dulon and C{\'e}line Cand{\'e} and Nigel W Bunnett and Morley D Hollenberg and Michel Chignard and Dominique Pidard},
  journal={American journal of respiratory cell and molecular biology},
  year={2003},
  volume={28 3},
  pages={339-46}
}
Proteinase-activated receptor (PAR)-2 is cleaved within its aminoterminal extracellular domain by serine proteinases such as trypsin, unmasking a new aminoterminus starting with the sequence SLIGKV, which binds intramolecularly and activates the receptor. PAR-2 has been reported to be involved in inflammation within the lungs. We show that PAR-2 is expressed not only by human alveolar (A549), but also by bronchial (16HBE) epithelial cell lines, using RT-PCR and flow cytometry with a PAR-2… CONTINUE READING