Proteinase-activated receptor 1 (PAR-1) and cell apoptosis


This review summarizes the main aspects and newest findings of how proteinase-activated receptor 1 (PAR-1) may modulate programmed cell death. Activation of PAR-1 has been found to induce or inhibit apoptosis in a variety of cells, depending on the dosage of its physiological agonist thrombin, or that of synthetic receptor activators. To date, cellular… (More)
DOI: 10.1023/B:APPT.0000045784.49886.96


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