Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2.

@article{Stenton2002ProteinaseactivatedR,
  title={Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2.},
  author={Grant R. Stenton and Osamu Nohara and Ren{\'e} E. D{\'e}ry and Harissios Vliagoftis and Mark Gilchrist and Ankur Johri and John L Wallace and Morley D Hollenberg and Redwan Moqbel and A Dean Befus},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={302 2},
  pages={466-74}
}
Because thrombin-induced inflammation is partially mast cell-dependent and involves proteinase-activated receptors (PARs), we hypothesized that mast cells express PAR and can be stimulated with PAR-activating peptides (PAR-AP). We demonstrated that rat peritoneal mast cells expressed PAR-1 and PAR-2 mRNA, and that PAR-2AP (tc-LIGRLO-NH(2), 1 microm) induced 64.2 +/- 4.4% specific beta-hexosaminidase release from peritoneal mast cells, whereas another PAR-2AP (SLIGRL-NH(2), 10 microM), trypsin… CONTINUE READING

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Desensitization of Ca(2 + ) flux with different agonists suggests that although tc - LIGRLO - NH(2 ) , Cit , and compound 48/80 have similar mechanisms of action , tc - LIGRLO - NH(2 ) also activates mast cells by a mechanism distinct from that of 48/80 .
Desensitization of Ca(2 + ) flux with different agonists suggests that although tc - LIGRLO - NH(2 ) , Cit , and compound 48/80 have similar mechanisms of action , tc - LIGRLO - NH(2 ) also activates mast cells by a mechanism distinct from that of 48/80 .
Desensitization of Ca(2 + ) flux with different agonists suggests that although tc - LIGRLO - NH(2 ) , Cit , and compound 48/80 have similar mechanisms of action , tc - LIGRLO - NH(2 ) also activates mast cells by a mechanism distinct from that of 48/80 .
Desensitization of Ca(2 + ) flux with different agonists suggests that although tc - LIGRLO - NH(2 ) , Cit , and compound 48/80 have similar mechanisms of action , tc - LIGRLO - NH(2 ) also activates mast cells by a mechanism distinct from that of 48/80 .
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