Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.

@article{Kessenbrock2008Proteinase3A,
  title={Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.},
  author={Kai Kessenbrock and Leopold Fr{\"o}hlich and Michael Sixt and Tim L{\"a}mmermann and Heiko Pfister and Andrew Bateman and Azzaq Belaaouaj and Johannes Ring and Markus W. Ollert and Reinhard F{\"a}ssler and Dieter E. Jenne},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 7},
  pages={
          2438-47
        }
}
Neutrophil granulocytes form the body's first line of antibacterial defense, but they also contribute to tissue injury and noninfectious, chronic inflammation. Proteinase 3 (PR3) and neutrophil elastase (NE) are 2 abundant neutrophil serine proteases implicated in antimicrobial defense with overlapping and potentially redundant substrate specificity. Here, we unraveled a cooperative role for PR3 and NE in neutrophil activation and noninfectious inflammation in vivo, which we believe to be novel… CONTINUE READING

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