Proteinase 3 Induces Neuronal Cell Death Through Microglial Activation

  title={Proteinase 3 Induces Neuronal Cell Death Through Microglial Activation},
  author={Kyu Suk Cho and Eun Joo Lee and Jung Nam Kim and Ji Woong Choi and Hahn Young Kim and Seol-Heui Han and Jong Hoon Ryu and Jae Hoon Cheong and Chan Young Shin and Kyoung Ja Kwon},
  journal={Neurochemical Research},
Proteinase 3 (PR3) is released from neutrophil granules and is involved in the inflammatory process. PR3 is implicated in antimicrobial defense and cell death, but the exact role of PR3 in the brain is less defined. Microglia is the major immune effector cells in the CNS and is activated by brain injury. In the present study, the effect of PR3 on glial activation was investigated. Microglial activation was assessed by the intracellular level of reactive oxygen species and expression of… Expand
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