Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis.

@article{Hilhorst2015Proteinase3V,
  title={Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis.},
  author={M. L. Hilhorst and Pieter van Paassen and Jan Willem Cohen Tervaert},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2015},
  volume={26 10},
  pages={
          2314-27
        }
}
In patients with GN or vasculitis, ANCAs are directed against proteinase 3 (PR3) or myeloperoxidase (MPO). The differences between PR3-ANCA-associated vasculitis (AAV) and MPO-AAV described in the past have been supplemented during the last decade. In this review, we discuss the differences between these two small-vessel vasculitides, focusing especially on possible etiologic and pathophysiologic differences. PR3-AAV is more common in northern parts of the world, whereas MPO-AAV is more common… CONTINUE READING

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