Proteinase‐resistant prion protein accumulation in Syrian hamster brain correlates with regional pathology and scrapie infectivity

@article{Jendroska1991ProteinaseresistantPP,
  title={Proteinase‐resistant prion protein accumulation in Syrian hamster brain correlates with regional pathology and scrapie infectivity},
  author={Klaus Jendroska and Frederick P. Heinzel and Marilyn Torchia and Linda Stowring and Hans A. Kretzschmar and A Kon and Arnold Stern and Stanley B. Prusiner and Stephen J. DeArmond},
  journal={Neurology},
  year={1991},
  volume={41},
  pages={1482 - 1482}
}
Multiple lines of evidence indicate that PrPSc, found only in scrapie, is a necessary component of the infectious scrapie agent. Equally compelling is the evidence that its accumulation in the brain causes the neuropathology characteristic of scrapie. We measured the regional concentration of PrPSc in nine brain regions throughout the course of scrapie in the Syrian hamster following intrathalamic inoculation of prions. PrPSc was compared to the regional concentration of glial fibrillary acidic… Expand
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