ProteinLasso: A Lasso regression approach to protein inference problem in shotgun proteomics

Abstract

Protein inference is an important issue in proteomics research. Its main objective is to select a proper subset of candidate proteins that best explain the observed peptides. Although many methods have been proposed for solving this problem, several issues such as peptide degeneracy and one-hit wonders still remain unsolved. Therefore, the accurate… (More)
DOI: 10.1016/j.compbiolchem.2012.12.008

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