Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells.

@article{Divekar2006ProteinVI,
  title={Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells.},
  author={Anagha A. Divekar and Dietmar M. Zaiss and F. Eun-Hyung Lee and Dacheng Liu and David J. Topham and Alice J. A. M. Sijts and Tim R. Mosmann},
  journal={Journal of immunology},
  year={2006},
  volume={176 3},
  pages={1465-73}
}
Mouse and human CD4 T cells primed during an immune response may differentiate into effector phenotypes such as Th1 (secreting IFN-gamma) or Th2 (secreting IL-4) that mediate effective immunity against different classes of pathogen. However, primed CD4 T cells can also remain uncommitted, secreting IL-2 and chemokines, but not IFN-gamma or IL-4. We now show that human CD4 T cells primed by protein vaccines mostly secreted IL-2, but not IFN-gamma, whereas in the same individuals most CD4 T cells… CONTINUE READING