Protein unfolding with a steric trap.

  title={Protein unfolding with a steric trap.},
  author={Tracy Mitchell Blois and Heedeok Hong and Tae Hyung Kim and James U. Bowie},
  journal={Journal of the American Chemical Society},
  volume={131 39},
The study of protein folding requires a method to drive unfolding, which is typically accomplished by altering solution conditions to favor the denatured state. This has the undesirable consequence that the molecular forces responsible for configuring the polypeptide chain are also changed. It would therefore be useful to develop methods that can drive unfolding without the need for destabilizing solvent conditions. Here we introduce a new method to accomplish this goal, which we call steric… CONTINUE READING

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Publications referenced by this paper.

Patent Number 5585277

  • J. U. Bowie, A.A.U.S. Pakula
  • J. Biomol. Screen
  • 1996

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