Protein unfolding by the mitochondrial membrane potential

@article{Huang2002ProteinUB,
  title={Protein unfolding by the mitochondrial membrane potential},
  author={Shihai Huang and Kevin S. Ratliff and Andreas Matouschek},
  journal={Nature Structural Biology},
  year={2002},
  volume={9},
  pages={301-307}
}
Mitochondria can unfold importing precursor proteins by unraveling them from their N-termini. However, how this unraveling is induced is not known. Two candidates for the unfolding activity are the electrical potential across the inner mitochondrial membrane and mitochondrial Hsp70 in the matrix. Here, we propose that many precursors are unfolded by the electrical potential acting directly on positively charged amino acid side chains in the targeting sequences. Only precursor proteins with… CONTINUE READING
48 Citations
53 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

model organism volumes of the BioKnowledge library, an integrated resource for protein information

  • Costanzo, M. C. et al. YPD, PombePD, WormPD
  • Nucleic Acids Res. 29, 75–79
  • 2001

Membrane potentialdriven protein import into mitochondria : the sorting sequence of cytochrome b 2 modulates the ∆ ψ − dependence of translocation of the matrixtargeting sequence

  • A. Geissler
  • Mol . Biol . Cell
  • 2000

Similar Papers

Loading similar papers…