Protein unfolding by the mitochondrial membrane potential

  title={Protein unfolding by the mitochondrial membrane potential},
  author={Shihai Huang and Kevin S. Ratliff and Andreas Matouschek},
  journal={Nature Structural Biology},
Mitochondria can unfold importing precursor proteins by unraveling them from their N-termini. However, how this unraveling is induced is not known. Two candidates for the unfolding activity are the electrical potential across the inner mitochondrial membrane and mitochondrial Hsp70 in the matrix. Here, we propose that many precursors are unfolded by the electrical potential acting directly on positively charged amino acid side chains in the targeting sequences. Only precursor proteins with… CONTINUE READING
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