Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils.

@article{Yousefi1994ProteintyrosinePR,
  title={Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils.},
  author={Shida Yousefi and Douglas R Green and Kelvin Blaser and Hans-Uwe Simon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 23},
  pages={
          10868-72
        }
}
Early signaling events that control the process of programmed cell death are largely unknown. Tyrosine phosphorylation plays a major role in transmembrane signal transduction through most cell surface receptors. Granulocyte/macrophage colony-stimulating factor (GM-CSF), a cytokine released by activated T cells, has been shown to increase tyrosine phosphorylation in several cells and to inhibit granulocyte cell death in vitro. In this study, we demonstrate that the effect of GM-CSF on… CONTINUE READING
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