Protein tyrosine phosphatases as adhesion receptors.

  title={Protein tyrosine phosphatases as adhesion receptors.},
  author={Susann M Brady-Kalnay and Nicholas K. Tonks},
  journal={Current opinion in cell biology},
  volume={7 5},
The intracellular segments of classic adhesion molecules such as N-CAM do not show structural similarity to any known signaling molecules. This suggests that their effects on signaling responses must be exerted indirectly through associated proteins. In contrast, many receptor protein tyrosine phosphatases (RPTPs) possess extracellular segments with homology to cell adhesion molecules linked directly to intracellular segments comprising one or two protein tyrosine phosphatase catalytic domains… CONTINUE READING

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