Protein tyrosine phosphatases and the immune response

@article{Mustelin2005ProteinTP,
  title={Protein tyrosine phosphatases and the immune response},
  author={Tomas Mustelin and Torkel Vang and Nunzio Bottini},
  journal={Nature Reviews Immunology},
  year={2005},
  volume={5},
  pages={43-57}
}
Reversible tyrosine phosphorylation of proteins is a key regulatory mechanism for numerous important aspects of eukaryotic physiology and is catalysed by kinases and phosphatases. Together, cells of the immune system express at least half of the 107 protein tyrosine phosphatase (PTP) genes in the human genome, most of which encode multidomain proteins that contain protein- and phospholipid-interaction domains. Here, we discuss the diverse but specific, and important, roles that PTPs have in… 
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