Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction.

@article{Tonks2013ProteinTP,
  title={Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction.},
  author={Nicholas K. Tonks},
  journal={The FEBS journal},
  year={2013},
  volume={280 2},
  pages={346-78}
}
There are many misconceptions surrounding the roles of protein phosphatases in the regulation of signal transduction, perhaps the most damaging of which is the erroneous view that these enzymes exert their effects merely as constitutively active housekeeping enzymes. On the contrary, the phosphatases are critical, specific regulators of signalling in their own right and serve an essential function, in a coordinated manner with the kinases, to determine the response to a physiological stimulus… CONTINUE READING
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