Protein-tyrosine phosphatases: structure, mechanism, and inhibitor discovery.

  title={Protein-tyrosine phosphatases: structure, mechanism, and inhibitor discovery.},
  author={Terrence R. Burke and Zhihong Zhang},
  volume={47 3},
Protein-tyrosine kinases (PTKs) and their associated signaling pathways are crucial for the regulation of numerous cell functions including growth, mitogenesis, motility, cell-cell interactions, metabolism, gene transcription, and the immune response. Since tyrosine phosphorylation is reversible and dynamic in vivo, the phosphorylation states of proteins are governed by the opposing actions of PTKs and protein-tyrosine phosphatases (PTPs). In this light, both PTKs and PTPs play equally… CONTINUE READING

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