Protein tyrosine phosphatases, new targets for cancer therapy.

  title={Protein tyrosine phosphatases, new targets for cancer therapy.},
  author={David J. Easty and William Gallagher and Daniel C. Bennett},
  journal={Current cancer drug targets},
  volume={6 6},
Cellular growth and development are regulated by reversible phosphorylation of tyrosine residues in target proteins. Protein tyrosine phosphatases (PTPs) catalyse removal, and protein tyrosine kinases (PTKs) the addition of phosphate. Data from various sources support a role for PTKs in transformation and it has long been hypothesized that some PTPs will function as tumour suppressor genes. Specific PTPs are down-regulated in some tumours, sometimes in association with ectopic expression of… CONTINUE READING