Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells.

Abstract

The role of protein-tyrosine phosphatase alpha (PTPalpha) in mast cell function was investigated in tissues and cells from PTPalpha-deficient mice. Bone marrow-derived mast cells (BMMCs) lacking PTPalpha exhibit defective stem cell factor (SCF)-dependent polarization and migration. Investigation of the molecular basis for this reveals that SCF/c-Kit… (More)
DOI: 10.1074/jbc.M804077200

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@article{Samayawardhena2008ProteintyrosinePA, title={Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells.}, author={Lionel A Samayawardhena and Catherine J. Pallen}, journal={The Journal of biological chemistry}, year={2008}, volume={283 43}, pages={29175-85} }