Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction.

@article{Haque1998ProteintyrosinePS,
  title={Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction.},
  author={Saikh Jaharul Haque and Phyllis C. Harbor and M. H. Nssehzadeh Tabrizi and Taolin Yi and Bret R. Williams},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 51},
  pages={33893-6}
}
Binding of interleukin (IL)-4 to its transmembrane receptor results in the Jak-mediated tyrosine phosphorylation of a number of protein components of the IL-4 signaling cascade, including Jak1, Jak2, Jak3, Tyk2, IL-4Ralpha, IRS-1, IRS-2, and Stat6 in appropriate cell types. However, the protein-tyrosine phosphatases (PTPs) that dephosphorylate these proteins and terminate signaling remained unidentified. We have noted that IL-4-dependent activation of Stat6 is sustained longer in fibroblasts… CONTINUE READING

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