Protein tyrosine phosphatase PTPN13 negatively regulates Her2/ErbB2 malignant signaling

Abstract

Deregulated Her2/ErbB2 receptor tyrosine kinase drives tumorigenesis and tumor progression in a variety of human tissues. Her2 transmits oncogenic signals through phosphorylation of its cytosolic domain. To study innate cellular mechanisms for containing Her2 oncogenic phosphorylation, a siRNA phosphatase library was screened for cellular phosphatase(s… (More)
DOI: 10.1038/sj.onc.1210922

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