Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer.

@article{Wu2006ProteinTP,
  title={Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer.},
  author={Chengyu Wu and Li Zhang and Patricia A. Bourne and Jay Reeder and P Anthony di Sant'agnese and Jorge Yao and Yanqun Na and Jiaoti Huang},
  journal={The Prostate},
  year={2006},
  volume={66 11},
  pages={1125-35}
}
BACKGROUND Prostate cancer (PC) contains a minor component of neuroendocrine (NE) cells that may stimulate androgen-independent growth of the tumor. The mechanism of neuroendocrine differentiation remains unknown. METHODS The expression of PTP1B, a protein tyrosine phosphatase, was studied in LNCaP cells induced to show neuroendocrine phenotype by androgen withdrawal. Wild-type PTP1B and its dominant-negative mutant were transfected into LNCaP cells to study their effects on neuroendocrine… CONTINUE READING

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