Protein tyrosine phosphatase-H2 from a polydnavirus induces apoptosis of insect cells.

@article{Suderman2008ProteinTP,
  title={Protein tyrosine phosphatase-H2 from a polydnavirus induces apoptosis of insect cells.},
  author={Richard J. Suderman and Andrea J P Pruijssers and Michael R Strand},
  journal={The Journal of general virology},
  year={2008},
  volume={89 Pt 6},
  pages={1411-20}
}
The family Polydnaviridae is a large group of immunosuppressive insect viruses that are symbiotically associated with parasitoid wasps. The polydnavirus Microplitis demolitor bracovirus (MdBV) causes several alterations that disable the cellular and humoral immune defences of host insects, including apoptosis of the primary phagocytic population of circulating immune cells (haemocytes), called granulocytes. Here, we show that MdBV infection causes granulocytes in the lepidopteran Spodoptera… CONTINUE READING
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