Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility.

@article{Zimmerman2014ProteintyrosineP4,
  title={Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility.},
  author={Mark W. Zimmerman and Kelley E. McQueeney and Jeffrey S. Isenberg and Bruce R. Pitt and Karla A Wasserloos and Gregg E Homanics and John S Lazo},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 9},
  pages={5904-13}
}
Protein-tyrosine phosphatase 4A3 (PTP4A3) is highly expressed in multiple human cancers and is hypothesized to have a critical, albeit poorly defined, role in the formation of experimental tumors in mice. PTP4A3 is broadly expressed in many tissues so the cellular basis of its etiological contributions to carcinogenesis may involve both tumor and stromal cells. In particular, PTP4A3 is expressed in the tumor vasculature and has been proposed to be a direct target of vascular endothelial growth… CONTINUE READING