Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.

@article{Rondinone2002ProteinTP,
  title={Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.},
  author={Cristina M. Rondinone and James M Trevillyan and Jill E Clampit and Rebecca J. Gum and Cathy E Berg and Paul E. Kroeger and Leigh J Frost and Bradley A Zinker and Regina M. Reilly and Roger G. Ulrich and Madeline Butler and Brett P. Monia and Michael R. Jirousek and Jeffrey F. Waring},
  journal={Diabetes},
  year={2002},
  volume={51 8},
  pages={2405-11}
}
Protein tyrosine phosphatase 1B (PTP1B) has been implicated as a negative regulator of insulin action. Overexpression of PTP1B protein has been observed in insulin-resistant states associated with obesity. Mice lacking a functional PTP1B gene exhibit increased insulin sensitivity and are resistant to weight gain. To investigate the role of PTP1B in adipose tissue from obese animals, hyperglycemic obese (ob/ob) mice were treated with PTP1B antisense oligonucleotide (ISIS-113715). A significant… CONTINUE READING
47 Extracted Citations
35 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 47 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 35 references

Anti-diabetic effects of protein PTP1B REGULATES LIPOGENESIS

  • B Zinker, J Clampit, +13 authors JR Jirousek
  • DIABETES,
  • 2002

Effects of protein phosphatase 1B (PTP1B) antisense oligonucleotide (ASO) treatment on fat volume using MRI in Zucker fatty rats (Abstract)

  • M Nuss, V Hradil, +8 authors B Zinker
  • Diabetes 50:A377,
  • 2001

Pharmacology of 2 -0-(2methoxy)ethyl modified antisense oligonucleotides

  • NM Dean, M Butler, BP Monia, M Manoharan
  • Crooke ST,
  • 2001

Similar Papers

Loading similar papers…