Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling.

@article{Heinonen2006ProteinTP,
  title={Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling.},
  author={Krista M Heinonen and Nadia Dub{\'e} and Annie Bourdeau and Wayne S. Lapp and Michel L Tremblay},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 8},
  pages={
          2776-81
        }
}
Protein tyrosine phosphatase 1B (PTP-1B) is a ubiquitously expressed cytosolic phosphatase with the ability to dephosphorylate JAK2 and TYK2, and thereby down-regulate cytokine receptor signaling. Furthermore, PTP-1B levels are up-regulated in certain chronic myelogenous leukemia patients, which points to a potential role for PTP-1B in myeloid development. The results presented here show that the absence of PTP-1B affects murine myelopoiesis by modifying the ratio of monocytes to granulocytes… CONTINUE READING

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IM M U N O LO G Y CSF1R myc (9E10) calnexin m oc k m oc k PT P1 B DA PT P1 B

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