Protein tyrosine phosphatase 1B inhibitors from Morus root bark.

@article{Cui2006ProteinTP,
  title={Protein tyrosine phosphatase 1B inhibitors from Morus root bark.},
  author={Long Hai Cui and MinKyun Na and Hyuncheol Oh and Eun Young Bae and Dae Gwin Jeong and Seong Eon Ryu and Sohee Kim and Bo Yeon Kim and Won Keun Oh and Jong Seog Ahn},
  journal={Bioorganic & medicinal chemistry letters},
  year={2006},
  volume={16 5},
  pages={1426-9}
}
An organic layer prepared from the Chinese crude drug 'Sang-Bai-Pi' (Morus root bark) was studied in order to identify the inhibitory compounds for protein tyrosine phosphatase 1B (PTP1B). Bioassay-guided fractionation resulted in the isolation of sanggenon C (1), sanggenon G (2), mulberrofuran C (3) and kuwanon L (4) as PTP1B inhibitors, along with moracin… CONTINUE READING