Protein-tyrosine phosphatase-1B (PTP1B) mediates the anti-migratory actions of Sprouty.

  title={Protein-tyrosine phosphatase-1B (PTP1B) mediates the anti-migratory actions of Sprouty.},
  author={Yinges Yigzaw and Helen Poppleton and Nair Sreejayan and Aviv Hassid and Tarun B. Patel},
  journal={The Journal of biological chemistry},
  volume={278 1},
Mammalian Sprouty proteins have been shown to inhibit the proliferation and migration of cells in response to growth factors and serum. In this communication, using HeLa cells, we have examined the possibility that human Sprouty 2 (hSPRY2) mediates its anti-migratory actions by modulating the activity or intracellular localization of protein-tyrosine phosphatases. In HeLa cells, overexpression of hSPRY2 resulted in an increase in protein-tyrosine phosphatase (PTP1B) amount and activity in the… CONTINUE READING


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