Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases.

Abstract

Phosphorylation of tyrosine residues within proteins, which is controlled by the reciprocal action of protein tyrosine kinases and protein tyrosine phosphatases, plays a key role in regulating almost all physiological responses. Therefore, it comes as no surprise that once the balance of tyrosine phosphorylation is disturbed, drastic effects can occur… (More)
DOI: 10.1016/j.tox.2015.08.006

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