Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases.


Phosphorylation of tyrosine residues within proteins, which is controlled by the reciprocal action of protein tyrosine kinases and protein tyrosine phosphatases, plays a key role in regulating almost all physiological responses. Therefore, it comes as no surprise that once the balance of tyrosine phosphorylation is disturbed, drastic effects can occur… (More)
DOI: 10.1016/j.tox.2015.08.006


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