Protein tyrosine phosphatase 1B: a new target for the treatment of obesity and associated co-morbidities.

@article{Ukkola2002ProteinTP,
  title={Protein tyrosine phosphatase 1B: a new target for the treatment of obesity and associated co-morbidities.},
  author={Olavi H Ukkola and Merja Santaniemi},
  journal={Journal of internal medicine},
  year={2002},
  volume={251 6},
  pages={467-75}
}
Impaired insulin action is important in the pathophysiology of multiple metabolic abnormalities such as obesity and type 2 diabetes. Protein tyrosine phosphatase 1B (PTP1B) is considered a negative regulator of insulin signalling. This is best evidenced by studies on knockout mice showing that lack of PTP1B is associated with increased insulin sensitivity as well as resistance to obesity and in vitro studies whilst studies in animals and humans have given contradictory results. However, several… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…