Protein tyrosine nitration in mouse peritoneal macrophages activated in vitro and in vivo: evidence against an essential role of peroxynitrite.

@article{Pfeiffer2001ProteinTN,
  title={Protein tyrosine nitration in mouse peritoneal macrophages activated in vitro and in vivo: evidence against an essential role of peroxynitrite.},
  author={Silvia Pfeiffer and Achim Lass and Keith R. Schmidt and Bernd Mayer},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2001},
  volume={15 13},
  pages={
          2355-64
        }
}
Tyrosine nitration is considered a key reaction of peroxynitrite-triggered tissue injury in inflammatory diseases. We investigated the potential involvement of peroxynitrite in protein tyrosine nitration in isolated murine peritoneal macrophages activated either in vitro with interferon-gamma/lipopolysaccharide or in vivo by priming mice with Corynebacterium parvum (10 mgxkg-1). Both protocols led to release of NO and accumulation of nitrite accompanied by formation of protein-bound 3… CONTINUE READING

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